The collection consists of two manuscripts. Both manuscripts include a section called, "Circuit Rider, or Seven Sides of the Itinerancy." The theme of itinerancy is present throughout both manuscripts. The photocopy of the original manuscript is incomplete. Other topics within these manuscripts are sermons, sermon outlines, life during the Civil War, poems, and an obituary.

The collection contains Thomas C. Nixon's journals beginning from 1815 to 1872. The journals reflect Nixon's daily activities including personal and business relationships, preaching, and his plantation activity among other topics. Here we see how Nixon's character develops over time and details related to his ministry, especially preaching, and his emotional reactions regarding suspension from the annual conference and the issue of slavery. The early journals discuss a great deal about his dedicated circuit-riding days whereas the later journals reflect on his life as a plantation owner. The collection also contains notebooks, loose journal pages, sermon notes, financial records, and clippings. There is also a photocopied collection of material related to the Nixon Family’s history which contains correspondences, copies of photographs, journals, notebooks, and sermons material along with additional family records.