The General Conference of the Church of the United Brethren in Christ of 1841 created a Missionary Society for missionary work at home and abroad. This organization's purpose was to promote and encourage missions, but had no administrative or operational authority to conduct mission work.
The General Conference of 1853 reorganized the Missionary Society and revised its constitution and its name was changed to the Home, Frontier, and Foreign Missionary Society.
Two missions were created in Southern Missouri and Canada and arrangements made to send missionaries to Africa. In 1855, William J. Shuey, Daniel C. Kumler, Daniel K. Flickinger sailed for Africa and set up missionary work at Freetown, Sierra Leone. Missionary work was established in China in 1889, Japan 1895, Puerto Rico 1899, and the Philippines in 1901. The General Conference of 1905 ordered the division of the Home, Frontier and Foreign Missionary Society into two separate organizations the Foreign Missionary Society and the Home Missionary Society. When the Church of the United Brethren in Christ merged with the Evangelical Church in 1946, the missionary societies of both churches were formed into a Board of Missions.